Who you calling obese, Doc?

Who Are You Calling a Squirt?

Lonidamine (LND) is a new anti-cancer drug which interferes with the energy-yielding processes of tumour cells without affecting DNA replication. A total of 69 previously untreated patients with non-small cell lung cancer (NSCLC) entered this study. LND was given orally as a single agent at doses ranging from 450 to 900 mg day-' until tumour progression (2 to > 1,402 days). Partial responses (P...

Are you kidding, doc?

Look who is calling: a comparison of genotype calling algorithms

In genome-wide association studies, high-level statistical analyses rely on the validity of the called genotypes, and different genotype calling algorithms (GCAs) have been proposed. We compared the GCAs Bayesian robust linear modeling using Mahalanobis distance (BRLMM), Chiamo++, and JAPL using the autosomal single-nucleotide polymorphisms (SNPs) from the 500 k Affymetrix Array Set data of the...

Calling All Agents, Where Are You?

We believe the next step in the application of agent technology to the Internet is the massive population of the Internet with software agents functioning in a wide range of capacities: information ltering, information brokering, commerce, negotiation, and so on. In such an environment, a means to eeectively locate relevant agents for relevant tasks is indispensable. In this paper, we examine i...

Geneva calling: WHO resolution on mental disorders

BACKGROUND A new resolution on mental, neurological and substance use disorders was adopted in January 2012 by the World Health Organization (WHO) Executive Board. The resolution urges WHO and Member States to collaborate in the development of a comprehensive mental health action plan, to be submitted for discussion and approval to the WHO World Health Assembly. This commentary aims at rising a...